Any feedback?
Literature summary for 5.6.2.1 extracted from
- Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations (2008), Nucleic Acids Res., 36, 5645-5651.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T729K | is resistant even at high concentration to camptothecin anti-cancer drug | Homo sapiens |
| T729P | mild reduction in drug sensitivity and in DNA binding | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| camptothecin | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P11387 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hTop1p | - |
Homo sapiens |
| human topoisomerase I | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
