Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme downregulation by topoisomerase I siRNA in HeLa cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(9-([2-(1H-Indol-3-yl)ethyl]amino)-3-acridinyl)(4-methyl-1-piperazinyl)methanone | - |
Homo sapiens | |
(9-([2-(1H-indol-3-yl)ethyl]amino)acridin-3-yl)(4-methylpiperazin-1-yl)methanone | - |
Homo sapiens | |
(9-([2-(1H-indol-3-yl)ethyl]amino)acridin-4-yl)(4-methylpiperazin-1-yl)methanone | - |
Homo sapiens | |
(9-[(1-benzylpiperidin-4-yl)amino]acridin-3-yl)(4-methylpiperazin-1-yl)methanone | - |
Homo sapiens | |
actinomycin D | traps topoisomerase I-DNA covalent complexes | Homo sapiens | |
amsacrine | - |
Homo sapiens | |
camptothecin | - |
Homo sapiens | |
doxorubicin | inhibits the enzyme without trapping cleavable complexes | Homo sapiens | |
additional information | cytotoxicity and mechanism of action of a series of substituted 9-aminoacridines is evaluated using topoisomerase I and cancer cell growth inhibition assays, overview | Homo sapiens | |
morpholinodoxorubicin | traps topoisomerase I-DNA covalent complexes | Homo sapiens | |
N,N-diethyl-9-([2-(1H-indol-3-yl)ethyl]amino)acridine-3-carboxamide | - |
Homo sapiens | |
pyrazoloacridine | completely suppresses the ability of topoisomerase I to relax supercoiled DNA at a concentration of 0.008 mM, inhibits the enzyme without trapping cleavable complexes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Homo sapiens | - |
DU-145 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MEL cell | melanoma cells | Homo sapiens | - |
OCL-3 cell | - |
Homo sapiens | - |
REH cell | renal carcinoma cells | Homo sapiens | - |
SU.86.86 cell | pancreatic cancer cells | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Topoisomerase I | - |
Homo sapiens |