Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.6.2.1 extracted from

  • Wang, P.; Ownby, S.; Zhang, Z.; Yuan, W.; Li, S.
    Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides (2010), Bioorg. Med. Chem. Lett., 20, 2790-2796.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aesculioside IIa
-
Homo sapiens
aesculioside IIb
-
Homo sapiens
aesculioside IIc
-
Homo sapiens
aesculioside IId
-
Homo sapiens
aesculioside IIIa
-
Homo sapiens
aesculioside IIIb
-
Homo sapiens
aesculioside IIIc
-
Homo sapiens
aesculioside IIId
-
Homo sapiens
aesculioside IIIe
-
Homo sapiens
aesculioside IIIf
-
Homo sapiens
aesculioside IV-23C1
-
Homo sapiens
aesculioside IV-23D1
-
Homo sapiens
aesculioside IV-23E
-
Homo sapiens
aesculioside IVa
-
Homo sapiens
aesculioside IVb
-
Homo sapiens
aesculioside IVc
-
Homo sapiens
additional information inhibitory potencies and cytotoxicities versus human cancer cell lines of plant-originated triterpenoids and triterpenoid glycosides isolated from Aesculus pavia, diverse inactive compounds, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
carcinoma cell
-
Homo sapiens
-
HL-60 cell
-
Homo sapiens
-
MRC-5 cell
-
Homo sapiens
-
PANC-1 cell
-
Homo sapiens
-
PC-3 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
DNA topoisomerase I
-
Homo sapiens
Top1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.024
-
-
Homo sapiens aesculioside IId
0.027
-
-
Homo sapiens aesculioside IV-23D1
0.033
-
-
Homo sapiens aesculioside IV-23E
0.036
-
-
Homo sapiens aesculioside IVb
0.045
-
-
Homo sapiens aesculioside IIIe
0.049
-
-
Homo sapiens aesculioside IIId
0.05
-
-
Homo sapiens aesculioside IVc
0.052
-
-
Homo sapiens aesculioside IVa
0.053
-
-
Homo sapiens aesculioside IV-23C1
0.054
-
-
Homo sapiens aesculioside IIIf
0.109
-
-
Homo sapiens aesculioside IIa
0.111
-
-
Homo sapiens aesculioside IIc
0.118
-
-
Homo sapiens aesculioside IIb
0.119
-
-
Homo sapiens aesculioside IIIa
0.132
-
-
Homo sapiens aesculioside IIIc
0.16
-
-
Homo sapiens aesculioside IIIb