Literature summary for 5.6.2.1 extracted from

Shuai, L.; Wang, S.; Zhang, L.; Fu, B.; Zhou, X.
Cationic porphyrins and analogues as new DNA topoisomerase I and II inhibitors (2009), Chem. Biodivers., 6, 827-837.

Search for more literature for 5.6.2.1

Inhibitors

Inhibitors	Comment	Organism	Structure
(1,1',1'',1'''-[(1,4-dihydroporphyrin-5,10,15,20-tetrayl-k4N21,N22,N23,N24)tetrakis(benzene-4,1-diylmethanediyl)]tetrakis[1-methylpiperidiniumato(2-)])nickel(4+) tetraiodide	-	Homo sapiens
(1,1',1'',1'''-[(1,4-dihydroporphyrin-5,10,15,20-tetrayl-k4N21,N22,N23,N24)tetrakis(benzene-4,1-diylmethanediyl)]tetrakis[1-methylpiperidiniumato(2-)])zinc(4+) tetraiodide	-	Homo sapiens
(2,2',2'',2''',2'''',2''''',2'''''',2'''''''-[(5,28-dihydro-29H,31H-tetrabenzoporphine-2,3,9,10,16,17,23,24-octayl-k4N29,N30,N31,N32)octasulfanediyl]octakis(N,N-diethyl-N-methylethanaminiumato)(2-))zinc(8+) octaiodide	-	Homo sapiens
1,1',1'',1'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis(1-methylpiperidinium) tetraiodide	-	Homo sapiens
1,1',1'',1'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis[3-(ethoxycarbonyl)-1-methylpiperidinium] tetraiodide	-	Homo sapiens
1,1',1'',1'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis[3-(hydroxymethyl)-1-methylpiperidinium] tetraiodide	-	Homo sapiens
4,4',4'',4'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis(4-methylmorpholin-4-ium) tetraiodide	-	Homo sapiens
additional information	inhibition mechanisms of cationic porphyrins and analogues, overview	Homo sapiens
N,N',N'',N'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis(2-hydroxy-N,N-dimethylethanaminium) tetrabromide	-	Homo sapiens
N,N',N'',N'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis(N,N-dimethylanilinium) tetrabromide	-	Homo sapiens
N,N',N'',N'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis(N-ethyl-N-methylethanaminium) tetrabromide	-	Homo sapiens
N,N',N'',N'''-[1,4-dihydroporphyrin-5,10,15,20-tetrayltetrakis(benzene-4,1-diylmethanediyl)]tetrakis[2-hydroxy-N-(2-hydroxyethyl)-N-methylethanaminium] tetrabromide	-	Homo sapiens
[2,2',2'',2''',2'''',2''''',2''''''-([24-((2-[diethyl(methyl)ammonio]ethyl)sulfanyl)-14,19-dihydro-29H,31H-tetrabenzoporphine-2,3,9,10,16,17,23-heptayl-k4N29,N30,N31,N32]heptasulfanediyl)heptakis(N,N,N-trimethylethanaminiumato)(2-)]zinc(8+) octaiodide	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	substrate is supercoiled pBR322 DNA	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Topo I	-	Homo sapiens
Topoisomerase I	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.9	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)