Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-camptothecin | - |
Homo sapiens | |
(S)-camptothecin | - |
Mus musculus | |
8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. ARC-111 | Homo sapiens | |
8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. ARC-111 | Mus musculus | |
8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. Genz-644282 | Homo sapiens | |
8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. Genz-644282 | Mus musculus | |
additional information | topoisomerase I inhibitors act as anticancer drugs, overview. Bone marrow colony-forming unit, CFU, granulocyte macrophage CFU, and tumor cell CFU activity of topoisomerase I inhibitors, overview. CFU are bipotent hemopoietic stem cells. Human bone marrow colony-forming unit is more sensitive to the Top1 inhibitors than is mouse bone marrow colony-forming unit | Homo sapiens | |
additional information | topoisomerase I inhibitors act as anticancer drugs, overview. Bone marrow colony-forming unit, CFU, granulocyte macrophage CFU, and tumor cell CFU activity of topoisomerase I inhibitors, overview. CFU are bipotent hemopoietic stem cells. Human bone marrow colony-forming unit is more sensitive to the Top1 inhibitors than is mouse bone marrow colony-forming unit | Mus musculus | |
SN-38 | - |
Homo sapiens | |
SN-38 | - |
Mus musculus | |
topotecan | - |
Homo sapiens | |
topotecan | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
male mice | - |
Mus musculus BALB/c | - |
male mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow cell | - |
Mus musculus | - |
bone marrow cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
DLD-1 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HCT-15 cell | - |
Homo sapiens | - |
hematopoietic stem cell | bipotent hemopoietic stem cells | Mus musculus | - |
hematopoietic stem cell | bipotent hemopoietic stem cells | Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
KB-3-1 cell | - |
Homo sapiens | - |
KB-V1 cell | - |
Homo sapiens | - |
KBH5.0 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
melanoma cell | - |
Homo sapiens | - |
non-small cell lung cancer cell | - |
Homo sapiens | - |
RCC 786-O cell | - |
Homo sapiens | - |
renal cell carcinoma cell | - |
Homo sapiens | - |
RPMI-8226 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Top1 | - |
Mus musculus |
Top1 | - |
Homo sapiens |
Topoisomerase I | - |
Mus musculus |
Topoisomerase I | - |
Homo sapiens |