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Literature summary for 5.6.2.1 extracted from

  • Yu, L.M.; Zhang, X.R.; Li, X.B.; Yang, Y.; Wei, H.Y.; He, X.X.; Gu, L.Q.; Huang, Z.S.; Pommier, Y.; An, L.K.
    Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors (2015), Eur. J. Med. Chem., 101, 525-533 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
2-(piperidin-1-yl)ethyl5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
2-(pyridin-2-yl)ethyl5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
2-(pyrrolidin-1-yl)ethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
2-bromoethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
3-(piperidin-1-yl)propyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
3-(pyrrolidin-1-yl)propyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
3-bromopropyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
3-morpholinopropyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylic acid
-
 Homo sapiens
5,12-dioxo-N-(2-(piperidin-1-yl)ethyl)-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
5,12-dioxo-N-(3-(piperidin-1-yl)propyl)-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
5,12-dioxo-N-(3-(pyrrolidin-1-yl)propyl)-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
5,12-dioxo-N-(3-phenylpropyl)-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
5,12-dioxo-N-phenethyl-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
6-(4-methylpiperazine-1-carbonyl)indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-(morpholine-4-carbonyl)indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
6-(piperidine-1-carbonyl)indolizino[2,3-g]quinoline-5,12-dione
-
 Homo sapiens
belotecan
-
 Homo sapiens
camptothecin
-
 Homo sapiens
ethyl 5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxylate
-
 Homo sapiens
irinotecan
-
 Homo sapiens
N,N-diethyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(2-(1H-imidazol-1-yl)ethyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(2-(4-methylpiperazin-1-yl)ethyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(2-(dimethylamino)ethyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(2-(pyrrolidin-1-yl)ethyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(2-morpholinoethyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(3-(4-methylpiperazin-1-yl)propyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(3-(diethylamino)propyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(3-(dimethylamino)propyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-(3-morpholinopropyl)-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
N-ethyl-5,12-dioxo-5,12-dihydroindolizino[2,3-g]quinoline-6-carboxamide
-
 Homo sapiens
topotecan
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
CA-46 cell
-
 Homo sapiens
-
GLC-82 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
NCI-H460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
117-base pair DNA oligonucleotide
-
 Homo sapiens ?
-
 ?
relaxed pBR322 DNA
-
 Homo sapiens ?
-
 ?
supercoiled pBR322 DNA
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
DNA topoisomerase I
-
 Homo sapiens
Top1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.025
-
 at pH 7.5 and 25°C Homo sapiens camptothecin