Literature summary for 5.6.2.2 extracted from

Choi, J.Y.; Seo, C.S.; Zheng, M.S.; Lee, C.S.; Son, J.K.
Topoisomerase I and II inhibitory constituents from the bark of Tilia amurensis (2008), Arch. Pharm. Res., 31, 1413-1418.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(-)-epicatechin	98% inhibition at 0.1 mM	Homo sapiens
(9S,12S,13S)-trihydroxy-(10E)-octadecenoic acid	97% inhibition at 0.1 mM	Homo sapiens
6-methoxy-7,8-methylenedioxycoumarin	57% inhibition at 0.1 mM	Homo sapiens
etoposide	78% inhibition at 0.1 mM	Homo sapiens
lyoniside	12% inhibition at 0.1 mM	Homo sapiens
nudiposide	9% inhibition at 0.1 mM	Homo sapiens
scopoletin	16% inhibition at 0.1 mM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled pBR 322 plasmid DNA + ATP + H2O	-	Homo sapiens	relaxed pBR 322 plasmid DNA + ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Topoisomerase II	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)