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Literature summary for 6.1.1.10 extracted from

  • Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Kang, M.K.; Jo, Y.J.; Kim, S.
    Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases (2001), Bioorg. Med. Chem. Lett., 11, 961-964.
    View publication on PubMed
Search for more literature for 6.1.1.10

Inhibitors

Inhibitors Comment Organism Structure
ester analogues of L-methionyl adenylate overview, modeling of interaction with the active site Escherichia coli
hydroxamate analogues of L-methionyl adenylate overview, modeling of the interaction with the active site Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Escherichia coli
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 class I enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
 Escherichia coli AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

Synonyms Comment Organism
Methionine translase
-
 Escherichia coli
Methionine--tRNA ligase
-
 Escherichia coli
Methionyl tRNA synthetase
-
 Escherichia coli
Methionyl-transfer ribonucleate synthetase
-
 Escherichia coli
Methionyl-transfer ribonucleic acid synthetase
-
 Escherichia coli
Methionyl-transfer RNA synthetase
-
 Escherichia coli
MetRS
-
 Escherichia coli
Synthetase, methionyl-transfer ribonucleate
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Escherichia coli