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Literature summary for 6.1.1.12 extracted from
- Aspartyl tRNA-synthetase from Escherichia coli: flexibility and adaptability to the substrates (2000), J. Mol. Biol., 299, 1157-1164.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| purified recombinant enzyme, in ammonium sulfate, NaCl, bis Tris propane, isopropanol, X-ray diffraction structure determination at 2.7 A resolution and structure analysis | Escherichia coli |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65912 | - |
x * 65912, crystal structure determination | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate + tRNAAsp | Escherichia coli | - |
AMP + diphosphate + L-aspartyl-tRNAAsp | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
purified recombinant enzyme from overexpression | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp | active site structure | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-aspartate + tRNAAsp | - |
Escherichia coli | AMP + diphosphate + L-aspartyl-tRNAAsp | - |
? | |
| ATP + L-aspartate + tRNAAsp | conformational changes and conformational stability upon tRNA and adenylate binding | Escherichia coli | AMP + diphosphate + L-aspartyl-tRNAAsp | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 65912, crystal structure determination | Escherichia coli |
| More | domain structure | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Aspartic acid translase | - |
Escherichia coli |
| Aspartyl ribonucleate synthetase | - |
Escherichia coli |
| aspartyl ribonuleic synthetase | - |
Escherichia coli |
| Aspartyl-transfer ribonucleic acid synthetase | - |
Escherichia coli |
| Aspartyl-transfer RNA synthetase | - |
Escherichia coli |
| Aspartyl-tRNA synthetase | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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