Protein Variants | Comment | Organism |
---|---|---|
K198L | exchange of the conserved residue leads to a slightly increased binding of Asp, binding of Asn is strongly increased to the level of Asp, no ability to adenylate Asn, molecular dynamic simulation, binding mechansim and free energy | Escherichia coli |
K198L/D233E | slightly increased binding of Asp, binding of ASn is strongly increased to the level of Asp, no ability to adenylate Asn, molecular dynamic simulation, binding mechansim and free energy | Escherichia coli |
K198L/Q199E/D233E | binding of Asp is strongly reduced, no ability to adenylate Asn, molecular dynamic simulation, binding mechansim and free energy | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-aspartate + tRNAAsp | Escherichia coli | - |
AMP + diphosphate + L-aspartyl-tRNAAsp | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + L-aspartate + tRNAAsp = AMP + diphosphate + L-aspartyl-tRNAAsp | Asn binding sites K198 and H449, binding mechanism and free energies | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-asparagine + tRNAAsp | - |
Escherichia coli | AMP + diphosphate + L-asparaginyl-tRNAAsp | - |
? | |
ATP + L-aspartate + tRNAAsp | - |
Escherichia coli | AMP + diphosphate + L-aspartyl-tRNAAsp | - |
? | |
additional information | determination of binding free energies | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aspartic acid translase | - |
Escherichia coli |
Aspartyl ribonucleate synthetase | - |
Escherichia coli |
aspartyl ribonuleic synthetase | - |
Escherichia coli |
Aspartyl-transfer ribonucleic acid synthetase | - |
Escherichia coli |
Aspartyl-transfer RNA synthetase | - |
Escherichia coli |
Aspartyl-tRNA synthetase | - |
Escherichia coli |