Literature summary for 6.1.1.2 extracted from

Zhang, Z.; Alfonta, L.; Tian, F.; Bursulaya, B.; Uryu, S.; King, D.S.; Schultz, P.G.
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells (2004), Proc. Natl. Acad. Sci. USA, 101, 8882-8887.

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Protein Variants

Protein Variants	Comment	Organism
V144P	mutant selectively aminoacylates the cognate mutant opal suppressor tRNATrp(UCA) with 5-hydroxy-L-tryptophan and not with any endogenous amino acid	Bacillus subtilis

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 5-hydroxy-L-tryptophan + tRNATrp	mutant enzyme V144P selectively aminoacylates the cognate mutant opal suppressor tRNATrp(UCA) with 5-hydroxy-L-tryptophan and not with any endogenous amino acid	Bacillus subtilis	AMP + diphosphate + 5-hydroxy-L-tryptophan-tRNATrp	-	?
ATP + L-tryptophan + tRNATrp	BsTRpRS charges only the cognate mutant opal suppressor tRNATrp(UCA) and not endogenous mammalian tRNAs	Bacillus subtilis	AMP + diphosphate + L-tryptophan-tRNATrp	-	?

Synonyms

Synonyms	Comment	Organism
BsTRpRS	-	Bacillus subtilis

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Release 2023.1 (January 2023)