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Literature summary for 6.1.1.2 extracted from

  • Azim, M.K.; Budisa, N.
    Docking of tryptophanyl [corrected tryptophan] analogs to trytophanyl-tRNA synthetase: implications for non-canonical amino acid incorporations (2008), Biol. Chem., 389, 1173-1182.
    View publication on PubMed
Search for more literature for 6.1.1.2

Application

Application Comment Organism
biotechnology EcTrpRS is used as a model system for in silicio docking studies with various Trp analogs using the FlexX-Pharm strategy. Relative binding energies for Trp analogs in TrpRS are calculated that correlate well with their translational activities in Escherichia coli. FlexX-Pharm predicted the binding sites of fluoro-, amino-, hydroxyl- and aza-containing Trp analogs within 1.5 A of Trp in the homology model of EcTrpRS Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-azatryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 2-azatryptophyl-tRNATrp
-
 ?
ATP + 4,5,6,7-tetrafluorotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 4,5,6,7-tetrafluorotryptophyl-tRNATrp
-
 ?
ATP + 4-aminotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 4-aminotryptophyl-tRNATrp
-
 ?
ATP + 4-fluorotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 4-fluorotryptophyl-tRNATrp
-
 ?
ATP + 4-hydroxytryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 4-hydroxytryptophyl-tRNATrp
-
 ?
ATP + 4-methyltryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 4-methyltryptophyl-tRNATrp
-
 ?
ATP + 5-aminotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 5-aminotryptophyl-tRNATrp
-
 ?
ATP + 5-bromotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 5-bromotryptophyl-tRNATrp
-
 ?
ATP + 5-fluorotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 5-fluorotryptophyl-tRNATrp
-
 ?
ATP + 5-hydroxytryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 5-hydroxytryptophyl-tRNATrp
-
 ?
ATP + 5-iodotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 5-iodotryptophyl-tRNATrp
-
 ?
ATP + 5-methoxytryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 5-methoxytryptophyl-tRNATrp
-
 ?
ATP + 5-methyltryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 5-methyltryptophyl-tRNATrp
-
 ?
ATP + 6-aminotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 6-aminotryptophyl-tRNATrp
-
 ?
ATP + 6-fluorotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 6-fluorotryptophyl-tRNATrp
-
 ?
ATP + 6-methyltryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 6-methyltryptophyl-tRNATrp
-
 ?
ATP + 7-aminotryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 7-aminotryptophyl-tRNATrp
-
 ?
ATP + 7-azatryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 7-azatryptophyl-tRNATrp
-
 ?
ATP + 7-methyltryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + 7-methyltryptophyl-tRNATrp
-
 ?
ATP + L-tryptophan + tRNATrp
-
 Escherichia coli AMP + diphosphate + L-tryptophyl-tRNATrp
-
 ?

Synonyms

Synonyms Comment Organism
EcTrpRS
-
 Escherichia coli
trytophanyl-tRNA synthetase
-
 Escherichia coli