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Literature summary for 6.1.1.2 extracted from

  • Ghanipour, A.; Jirstroem, K.; Ponten, F.; Glimelius, B.; Pahlman, L.; Birgisson, H.
    The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer (2009), Cancer Epidemiol. Biomarkers Prev., 18, 2949-2956.
    View publication on PubMed
Search for more literature for 6.1.1.2

Application

Application Comment Organism
medicine TrpRS is differentially expressed in colorectal cancer and thus a potential prognostic marker Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tryptophan + tRNATrp Homo sapiens
-
 AMP + diphosphate + L-tryptophyl-tRNATrp
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tryptophan + tRNATrp
-
 Homo sapiens AMP + diphosphate + L-tryptophyl-tRNATrp
-
 ?

Synonyms

Synonyms Comment Organism
TrpRS
-
 Homo sapiens
Tryptophanyl-tRNA synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function TrpRS is an aminoacyl-tRNA synthetase involved in protein synthesis and regulation of RNA transcription and translation and is an inhibitor of angiogenesis Homo sapiens