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Literature summary for 6.1.1.2 extracted from

  • Lee, C.W.; Chang, K.P.; Chen, Y.Y.; Liang, Y.; Hsueh, C.; Yu, J.S.; Chang, Y.S.; Yu, C.J.
    Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness (2015), Oncotarget, 6, 21979-21992 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.2

Cloned(Commentary)

Cloned (Comment) Organism
tryptophanyl-tRNA synthetase (TrpRS) is a 53-kDa protein that consists of 471 amino acids, and a mini-TrpRS (residues 48-471) isoform is produced by alternative splicing, recombinant full-length, mini- or T2-TrpRS are constructed and expressed in OEC-M1 cells lacking endogenous TrpRS activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information generation of TrpRS-knockdown OEC-M1 cells by siRNA expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
extracellular the enzyme is secreted Homo sapiens
-
-
additional information subcellular localization study Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information both full-length TrpRS and mini-TrpRS can be mobilized for exocytosis from endothelial cells, and the secreted TrpRS is cleaved by extracellular proteases to produce two additional N-terminally truncated fragments: T1-TrpRS (residues 71-471) and T2-TrpRS (residues 94-471) Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
additional information TrpRS levels are significantly higher in tumor cells from metastatic lymph nodes than in corresponding primary tumor cells Homo sapiens
-
OC-3 cell
-
 Homo sapiens
-
oral squamous cell carcinoma cell enzyme TrpRS is overexpressed in OSCC tissues (139/146, 95.2%) compared with adjacent normal tissues. TrpRS knockdown or treatment with conditioned media obtained from TrpRS-knockdown cells significantly reduce oral cancer cell viability and invasiveness. TrpRS overexpression promotes cell migration and invasion. In addition, the extracellular addition of TrpRS rescues the invasion ability of TrpRS-knockdown cells. No significant association between TrpRS level and gender, age or N stage Homo sapiens
-

Synonyms

Synonyms Comment Organism
Tryptophanyl-tRNA synthetase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the angiostatic agent tryptophanyl-tRNA synthetase (TrpRS) is a dysregulated protein in oral squamous cell carcinoma (OSCC) based on a proteomics approach. TrpRS expression positively correlates with tumor stage, overall TNM stage, perineural invasion and tumor depth. TrpRS knockdown reduces cell viability and oral cancer cell migration and invasion Homo sapiens
additional information both full-length TrpRS and mini-TrpRS splicing variants can be mobilized for exocytosis from endothelial cells, and the secreted TrpRS is cleaved by extracellular proteases to produce two additional N-terminally truncated fragments: T1-TrpRS (residues 71-471) and T2-TrpRS (residues 94-471). Extracellular treatment of TrpRS promotes cell invasion in oral cancer cells Homo sapiens
physiological function secreted TrpRS promotes OSCC progression via an extrinsic pathway Homo sapiens