Inhibitors | Comment | Organism | Structure |
---|---|---|---|
chloramphenicol | - |
Haemophilus influenzae | |
chloramphenicol | - |
Moraxella catarrhalis | |
chloramphenicol | - |
Staphylococcus aureus | |
chloramphenicol | - |
Streptococcus pneumoniae | |
Methicillin | - |
Haemophilus influenzae | |
Methicillin | - |
Moraxella catarrhalis | |
Methicillin | - |
Staphylococcus aureus | |
Methicillin | - |
Streptococcus pneumoniae | |
muciproin | - |
Escherichia coli | |
muciproin | - |
Haemophilus influenzae | |
muciproin | - |
Moraxella catarrhalis | |
muciproin | - |
Staphylococcus aureus | |
muciproin | - |
Streptococcus pneumoniae | |
phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine | Escherichia coli | |
phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Haemophilus influenzae | |
phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Moraxella catarrhalis | |
phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Staphylococcus aureus | |
phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Streptococcus pneumoniae | |
phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Haemophilus influenzae | |
phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Moraxella catarrhalis | |
phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Staphylococcus aureus | |
phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Streptococcus pneumoniae | |
phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindole | - |
Escherichia coli | |
phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Haemophilus influenzae | |
phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Moraxella catarrhalis | |
phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Staphylococcus aureus | |
phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Streptococcus pneumoniae | |
phenyl-thiazolylurea-sulfonamido-aminoethylindole | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-phenylalanine + tRNAPhe | Staphylococcus aureus | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Haemophilus influenzae | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Escherichia coli | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Streptococcus pneumoniae | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Moraxella catarrhalis | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Staphylococcus aureus 133 | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Streptococcus pneumoniae G9A | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Moraxella catarrhalis 489 | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | Haemophilus influenzae Spain 7 | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
purified enzyme, strain CP78 and mutant relA- strain CP79 | - |
Haemophilus influenzae | - |
clinical isolate | - |
Haemophilus influenzae Spain 7 | - |
clinical isolate | - |
Moraxella catarrhalis | - |
- |
- |
Moraxella catarrhalis 489 | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus 133 | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae G9A | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-phenylalanine + tRNAPhe | - |
Staphylococcus aureus | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Haemophilus influenzae | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Escherichia coli | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Streptococcus pneumoniae | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Moraxella catarrhalis | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Staphylococcus aureus 133 | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Streptococcus pneumoniae G9A | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Moraxella catarrhalis 489 | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
ATP + L-phenylalanine + tRNAPhe | - |
Haemophilus influenzae Spain 7 | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CML33 | - |
Staphylococcus aureus |
CML33 | - |
Haemophilus influenzae |
CML33 | - |
Escherichia coli |
CML33 | - |
Streptococcus pneumoniae |
CML33 | - |
Moraxella catarrhalis |
FRS | - |
Staphylococcus aureus |
FRS | - |
Haemophilus influenzae |
FRS | - |
Escherichia coli |
FRS | - |
Streptococcus pneumoniae |
FRS | - |
Moraxella catarrhalis |
HSPC173 | - |
Staphylococcus aureus |
HSPC173 | - |
Haemophilus influenzae |
HSPC173 | - |
Escherichia coli |
HSPC173 | - |
Streptococcus pneumoniae |
HSPC173 | - |
Moraxella catarrhalis |
L-Phenylalanyl-tRNA synthetase | - |
Staphylococcus aureus |
L-Phenylalanyl-tRNA synthetase | - |
Haemophilus influenzae |
L-Phenylalanyl-tRNA synthetase | - |
Escherichia coli |
L-Phenylalanyl-tRNA synthetase | - |
Streptococcus pneumoniae |
L-Phenylalanyl-tRNA synthetase | - |
Moraxella catarrhalis |
Phenylalanine translase | - |
Staphylococcus aureus |
Phenylalanine translase | - |
Haemophilus influenzae |
Phenylalanine translase | - |
Escherichia coli |
Phenylalanine translase | - |
Streptococcus pneumoniae |
Phenylalanine translase | - |
Moraxella catarrhalis |
Phenylalanine--tRNA ligase | - |
Staphylococcus aureus |
Phenylalanine--tRNA ligase | - |
Haemophilus influenzae |
Phenylalanine--tRNA ligase | - |
Escherichia coli |
Phenylalanine--tRNA ligase | - |
Streptococcus pneumoniae |
Phenylalanine--tRNA ligase | - |
Moraxella catarrhalis |
Phenylalanine-tRNA synthetase | - |
Staphylococcus aureus |
Phenylalanine-tRNA synthetase | - |
Haemophilus influenzae |
Phenylalanine-tRNA synthetase | - |
Escherichia coli |
Phenylalanine-tRNA synthetase | - |
Streptococcus pneumoniae |
Phenylalanine-tRNA synthetase | - |
Moraxella catarrhalis |
Phenylalanyl transfer ribonucleic acid synthetase | - |
Staphylococcus aureus |
Phenylalanyl transfer ribonucleic acid synthetase | - |
Haemophilus influenzae |
Phenylalanyl transfer ribonucleic acid synthetase | - |
Escherichia coli |
Phenylalanyl transfer ribonucleic acid synthetase | - |
Streptococcus pneumoniae |
Phenylalanyl transfer ribonucleic acid synthetase | - |
Moraxella catarrhalis |
Phenylalanyl-transfer ribonucleate synthetase | - |
Staphylococcus aureus |
Phenylalanyl-transfer ribonucleate synthetase | - |
Haemophilus influenzae |
Phenylalanyl-transfer ribonucleate synthetase | - |
Escherichia coli |
Phenylalanyl-transfer ribonucleate synthetase | - |
Streptococcus pneumoniae |
Phenylalanyl-transfer ribonucleate synthetase | - |
Moraxella catarrhalis |
Phenylalanyl-transfer RNA ligase | - |
Staphylococcus aureus |
Phenylalanyl-transfer RNA ligase | - |
Haemophilus influenzae |
Phenylalanyl-transfer RNA ligase | - |
Escherichia coli |
Phenylalanyl-transfer RNA ligase | - |
Streptococcus pneumoniae |
Phenylalanyl-transfer RNA ligase | - |
Moraxella catarrhalis |
Phenylalanyl-transfer RNA synthetase | - |
Staphylococcus aureus |
Phenylalanyl-transfer RNA synthetase | - |
Haemophilus influenzae |
Phenylalanyl-transfer RNA synthetase | - |
Escherichia coli |
Phenylalanyl-transfer RNA synthetase | - |
Streptococcus pneumoniae |
Phenylalanyl-transfer RNA synthetase | - |
Moraxella catarrhalis |
Phenylalanyl-tRNA ligase | - |
Staphylococcus aureus |
Phenylalanyl-tRNA ligase | - |
Haemophilus influenzae |
Phenylalanyl-tRNA ligase | - |
Escherichia coli |
Phenylalanyl-tRNA ligase | - |
Streptococcus pneumoniae |
Phenylalanyl-tRNA ligase | - |
Moraxella catarrhalis |
Phenylalanyl-tRNA synthetase | - |
Staphylococcus aureus |
Phenylalanyl-tRNA synthetase | - |
Haemophilus influenzae |
Phenylalanyl-tRNA synthetase | - |
Escherichia coli |
Phenylalanyl-tRNA synthetase | - |
Streptococcus pneumoniae |
Phenylalanyl-tRNA synthetase | - |
Moraxella catarrhalis |
PheRS | - |
Staphylococcus aureus |
PheRS | - |
Haemophilus influenzae |
PheRS | - |
Escherichia coli |
PheRS | - |
Streptococcus pneumoniae |
PheRS | - |
Moraxella catarrhalis |
Synthetase, phenylalanyl-transfer ribonucleate | - |
Staphylococcus aureus |
Synthetase, phenylalanyl-transfer ribonucleate | - |
Haemophilus influenzae |
Synthetase, phenylalanyl-transfer ribonucleate | - |
Escherichia coli |
Synthetase, phenylalanyl-transfer ribonucleate | - |
Streptococcus pneumoniae |
Synthetase, phenylalanyl-transfer ribonucleate | - |
Moraxella catarrhalis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Staphylococcus aureus | |
ATP | - |
Haemophilus influenzae | |
ATP | - |
Escherichia coli | |
ATP | - |
Streptococcus pneumoniae | |
ATP | - |
Moraxella catarrhalis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Staphylococcus aureus | |
additional information | - |
additional information | - |
Haemophilus influenzae | |
additional information | - |
additional information | - |
Escherichia coli | |
additional information | - |
additional information | - |
Streptococcus pneumoniae | |
additional information | - |
additional information | - |
Moraxella catarrhalis | |
0.000021 | - |
phenyl-thiazolylurea-sulfonamido-aminoethylindole | pH 7.6, 22°C | Escherichia coli |