Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-[3-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]propanoyl-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 10% inhibition at 0.1 mM | Rattus norvegicus | |
7-[4-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]butanoyl-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 18% inhibition at 0.1 mM | Rattus norvegicus | |
7-[4-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]butanoyl-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 26% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]acetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 17% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | - |
Rattus norvegicus | |
7-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | - |
Staphylococcus aureus | |
7-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxylic acid methyl ester | derivative of SB-203207, 49% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxylic acid methyl ester | derivative of SB-203207, 31% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-4,4a,5,6,7,7a-hexahydro-1-methyl-1H-cyclopenta[b]pyridine-3-carboxylic acid methyl ester | derivative of SB-203207, 46% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-4,4a,5,6,7,7a-hexahydro-1-methyl-1H-cyclopenta[b]pyridine-3-carboxylic acid methyl ester | derivative of SB-203207, 34% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(S)-2-amino-1-oxo-5-thiahexyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 31% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(S)-2-amino-1-oxo-5-thiahexyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 38% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(S)-2-amino-1-oxo-hexyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 17% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(S)-2-amino-1-oxo-hexyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxamide | derivative of SB-203207, 46% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(S)-2-amino-3-methyl-1-oxobutyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxylic acid methyl ester | derivative of SB-203207, 31% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(S)-2-amino-3-methyl-1-oxobutyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxylic acid methyl ester | derivative of SB-203207, 38% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(S)-2-amino-3-methyl-1-oxobutyl]amino]sulfonylacetyloxy-4,4a,5,6,7,7a-hexahydro-1-methyl-1H-cyclopenta[b]pyridine-3-carboxylic acid methyl ester | derivative of SB-203207, 33% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(S)-2-amino-3-methyl-1-oxobutyl]amino]sulfonylacetyloxy-4,4a,5,6,7,7a-hexahydro-1-methyl-1H-cyclopenta[b]pyridine-3-carboxylic acid methyl ester | derivative of SB-203207, 10% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-4,4a,5,6,7,7a-hexahydro-1-methyl-1H-cyclopenta[b]pyridine-3-carboxylic acid methyl ester | derivative of SB-203207, 13% inhibition at 0.1 mM | Rattus norvegicus | |
7-[[(S)-2-amino-3-methyl-1-oxopentyl]amino]sulfonylacetyloxy-4,4a,5,6,7,7a-hexahydro-1-methyl-1H-cyclopenta[b]pyridine-3-carboxylic acid methyl ester | derivative of SB-203207, 15% inhibition at 0.1 mM | Staphylococcus aureus | |
7-[[(S)-2-amino-4-methyl-1-oxopentyl]amino]sulfonylacetyloxy-2,4a,5,6,7,7a-hexahydro-2-methyl-1H-cyclopenta[c]pyridine-4-carboxylic acid methyl ester | derivative of SB-203207, 14% inhibition at 0.1 mM | Rattus norvegicus | |
additional information | diverse analogues of SB-203207 are not inhibitory, overview | Rattus norvegicus | |
additional information | diverse analogues of SB-203207 are not inhibitory, overview | Staphylococcus aureus | |
SB-203207 | anti-infective agent, isolated from Streptomyces NCIMB 40513, analogous to the reaction intermediate | Rattus norvegicus | |
SB-203207 | anti-infective agent, isolated from Streptomyces NCIMB 40513, analogous to the reaction intermediate | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-isoleucine + tRNAIle | Staphylococcus aureus | - |
AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
ATP + L-isoleucine + tRNAIle | Rattus norvegicus | - |
AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
ATP + L-isoleucine + tRNAIle | Staphylococcus aureus WCUH29 | - |
AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus WCUH29 | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-isoleucine + tRNAIle | - |
Staphylococcus aureus | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
ATP + L-isoleucine + tRNAIle | - |
Rattus norvegicus | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
ATP + L-isoleucine + tRNAIle | - |
Staphylococcus aureus WCUH29 | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IleRS | - |
Staphylococcus aureus |
IleRS | - |
Rattus norvegicus |
IRS | - |
Staphylococcus aureus |
IRS | - |
Rattus norvegicus |
Isoleucine translase | - |
Staphylococcus aureus |
Isoleucine translase | - |
Rattus norvegicus |
Isoleucine--tRNA ligase | - |
Staphylococcus aureus |
Isoleucine--tRNA ligase | - |
Rattus norvegicus |
Isoleucine-transfer RNA ligase | - |
Staphylococcus aureus |
Isoleucine-transfer RNA ligase | - |
Rattus norvegicus |
Isoleucine-tRNA synthetase | - |
Staphylococcus aureus |
Isoleucine-tRNA synthetase | - |
Rattus norvegicus |
Isoleucyl-transfer ribonucleate synthetase | - |
Staphylococcus aureus |
Isoleucyl-transfer ribonucleate synthetase | - |
Rattus norvegicus |
Isoleucyl-transfer RNA synthetase | - |
Staphylococcus aureus |
Isoleucyl-transfer RNA synthetase | - |
Rattus norvegicus |
Isoleucyl-tRNA synthetase | - |
Staphylococcus aureus |
Isoleucyl-tRNA synthetase | - |
Rattus norvegicus |
Mupirocin resistance protein | - |
Staphylococcus aureus |
Mupirocin resistance protein | - |
Rattus norvegicus |
Synthetase, isoleucyl-transfer ribonucleate | - |
Staphylococcus aureus |
Synthetase, isoleucyl-transfer ribonucleate | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Staphylococcus aureus | |
ATP | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Staphylococcus aureus | |
additional information | - |
additional information | - |
Rattus norvegicus |