Literature summary for 6.1.1.5 extracted from

Lee, J.; Kang, S.U.; Kim, S.Y.; Kim, S.E.; Job, Y.J.; Kim, S.
Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases (2001), Bioorg. Med. Chem. Lett., 11, 965-968.

Search for more literature for 6.1.1.5

Inhibitors

Inhibitors	Comment	Organism	Structure
isoleucyl isovanilloids	e.g. the isovanillic hydroxamate and amide analogue	Escherichia coli
isoleucyl vanilloids	e.g. the vanillic hydroxamate with a phenolic hydoxyl at the para-position	Escherichia coli
additional information	the ribose of ATP/AMP can be substituted by its biosteres acyclic amide, hydroxamate, dihydroisooxazole, and dihydrooxazole, binding structure, overview	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-isoleucine + tRNAIle	Escherichia coli	-	AMP + diphosphate + L-isoleucyl-tRNAIle	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-isoleucine + tRNAIle	-	Escherichia coli	AMP + diphosphate + L-isoleucyl-tRNAIle	-	?

Synonyms

Synonyms	Comment	Organism
IleRS	-	Escherichia coli
IRS	-	Escherichia coli
Isoleucine translase	-	Escherichia coli
Isoleucine--tRNA ligase	-	Escherichia coli
Isoleucine-transfer RNA ligase	-	Escherichia coli
Isoleucine-tRNA synthetase	-	Escherichia coli
Isoleucyl-transfer ribonucleate synthetase	-	Escherichia coli
Isoleucyl-transfer RNA synthetase	-	Escherichia coli
Isoleucyl-tRNA synthetase	-	Escherichia coli
Mupirocin resistance protein	-	Escherichia coli
Synthetase, isoleucyl-transfer ribonucleate	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Escherichia coli

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Release 2023.1 (January 2023)