Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.6 extracted from

  • Nathanson, L.; Deutscher, M.P.
    Active aminoacyl-tRNA synthetases are present in nuclei as a high molecular weight multienzyme complex (2000), J. Biol. Chem., 275, 31559-31562.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Cricetulus griseus 5737
-
cytoplasm major part, enzyme participates in a multienzyme complex, not as large and stable as the one from nucleus Oryctolagus cuniculus 5737
-
nucleus 0.67% of total enzyme amount in the cell, enzyme participates in a large and stable multienzyme complex Oryctolagus cuniculus 5634
-
nucleus 3.1% of total enzyme amount in the cell, enzyme participates in a large and stable multienzyme complex Cricetulus griseus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-lysine + tRNALys Cricetulus griseus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-lysyl-tRNALys
-
?
ATP + L-lysine + tRNALys Oryctolagus cuniculus the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm AMP + diphosphate + L-lysyl-tRNALys
-
?
additional information Cricetulus griseus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
?
additional information Oryctolagus cuniculus aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I ?
-
?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney cell line LCC-RK1 Oryctolagus cuniculus
-
ovary cell line CRL-1781 Cricetulus griseus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Cricetulus griseus
additional information
-
-
Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
-
Cricetulus griseus AMP + diphosphate + L-lysyl-tRNALys
-
?
ATP + L-lysine + tRNALys
-
Oryctolagus cuniculus AMP + diphosphate + L-lysyl-tRNALys
-
?
ATP + L-lysine + tRNALys the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Cricetulus griseus AMP + diphosphate + L-lysyl-tRNALys
-
?
ATP + L-lysine + tRNALys the reaction catalyzed by the enzyme plays an important role in the transport of aminoacylated tRNAs from the nucleus to the cytoplasm Oryctolagus cuniculus AMP + diphosphate + L-lysyl-tRNALys
-
?
additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Cricetulus griseus ?
-
?
additional information aminoacyl-tRNA is channeled in vivo by probably direct transfer to elongation factor I Oryctolagus cuniculus ?
-
?

Synonyms

Synonyms Comment Organism
L-Lysine-transfer RNA ligase
-
Cricetulus griseus
L-Lysine-transfer RNA ligase
-
Oryctolagus cuniculus
Lysine translase
-
Cricetulus griseus
Lysine translase
-
Oryctolagus cuniculus
Lysine--tRNA ligase
-
Cricetulus griseus
Lysine--tRNA ligase
-
Oryctolagus cuniculus
Lysine-tRNA synthetase
-
Cricetulus griseus
Lysine-tRNA synthetase
-
Oryctolagus cuniculus
LysRS
-
Cricetulus griseus
LysRS
-
Oryctolagus cuniculus
Lysyl-transfer ribonucleate synthetase
-
Cricetulus griseus
Lysyl-transfer ribonucleate synthetase
-
Oryctolagus cuniculus
Lysyl-transfer RNA synthetase
-
Cricetulus griseus
Lysyl-transfer RNA synthetase
-
Oryctolagus cuniculus
Lysyl-tRNA synthetase
-
Cricetulus griseus
Lysyl-tRNA synthetase
-
Oryctolagus cuniculus
Synthetase, lysyl-transfer ribonucleate
-
Cricetulus griseus
Synthetase, lysyl-transfer ribonucleate
-
Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Cricetulus griseus
37
-
assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Cricetulus griseus
7.5
-
assay at Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Cricetulus griseus
ATP
-
Oryctolagus cuniculus