KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.6 | - |
D-2-hydroxybutanoate | pH 8.6, 25°C | Enterococcus faecium | |
3.2 | - |
D-2-hydroxyvalerate | pH 8.6, 25°C | Enterococcus faecium | |
7.1 | - |
D-lactate | pH 8.6, 25°C | Enterococcus faecium | |
38 | - |
D-Ala | pH 8.6, 25°C | Enterococcus faecium |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterococcus faecium | - |
BM4147 | - |
Enterococcus faecium BM4147 | - |
BM4147 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Ala + D-2-hydroxybutanoate + ATP | - |
Enterococcus faecium | D-Ala-D-2-hydroxybutanoate + ADP + phosphate | - |
? | |
D-Ala + D-2-hydroxybutanoate + ATP | - |
Enterococcus faecium BM4147 | D-Ala-D-2-hydroxybutanoate + ADP + phosphate | - |
? | |
D-Ala + D-2-hydroxyvalerate + ATP | - |
Enterococcus faecium | D-Ala-D-2-hydroxyvalerate + ADP + phosphate | - |
? | |
D-Ala + D-2-hydroxyvalerate + ATP | - |
Enterococcus faecium BM4147 | D-Ala-D-2-hydroxyvalerate + ADP + phosphate | - |
? | |
D-Ala + D-Ala + ATP | - |
Enterococcus faecium | D-Ala-D-Ala + ADP + phosphate | - |
? | |
D-Ala + D-Ala + ATP | - |
Enterococcus faecium BM4147 | D-Ala-D-Ala + ADP + phosphate | - |
? | |
D-Ala + D-lactate + ATP | - |
Enterococcus faecium | D-Ala-D-lactate + ADP + phosphate | - |
? | |
D-Ala + D-lactate + ATP | - |
Enterococcus faecium BM4147 | D-Ala-D-lactate + ADP + phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.57 | - |
D-lactate | pH 8.6, 25°C | Enterococcus faecium | |
1.8 | - |
D-2-hydroxybutanoate | pH 8.6, 25°C | Enterococcus faecium | |
2.6 | - |
D-2-hydroxyvalerate | pH 8.6, 25°C | Enterococcus faecium | |
4.92 | - |
D-Ala | pH 8.6, 25°C | Enterococcus faecium |
General Information | Comment | Organism |
---|---|---|
physiological function | VanA is a D-alanine:D-alanine ligase of altered substrate specificity. VanA catalyzes ester bond formation between D-alanine and the D-hydroxy acid products of VanH, the best substrate being D-2-hydroxybutyrate. The VanA product D-alanyl-D-2-hydroxybutyrate can then be incorporated into the UDPMurNAc-pentapeptide peptidoglycan precursor | Enterococcus faecium |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
D-Ala | pH 8.6, 25°C | Enterococcus faecium | |
0.22 | - |
D-lactate | pH 8.6, 25°C | Enterococcus faecium | |
0.81 | - |
D-2-hydroxyvalerate | pH 8.6, 25°C | Enterococcus faecium | |
3 | - |
D-2-hydroxybutanoate | pH 8.6, 25°C | Enterococcus faecium |