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Literature summary for 6.1.2.1 extracted from

  • Bouvier, G.; Duclert-Savatier, N.; Desdouits, N.; Meziane-Cherif, D.; Blondel, A.; Courvalin, P.; Nilges, M.; Malliavin, T.E.
    Functional motions modulating VanA ligand binding unraveled by self-organizing maps (2014), J. Chem. Inf. Model., 54, 289-301.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alanine + (R)-lactate + ATP Enterococcus faecium
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
D-alanine + (R)-lactate + ATP Enterococcus faecium BM4147
-
 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Enterococcus faecium P25051
-
-
Enterococcus faecium BM4147 P25051
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + (R)-lactate + ATP
-
 Enterococcus faecium D-alanyl-(R)-lactate + ADP + phosphate
-
 ?
D-alanine + (R)-lactate + ATP
-
 Enterococcus faecium BM4147 D-alanyl-(R)-lactate + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
D-Ala:D-Lac ligase
-
 Enterococcus faecium
VanA
-
 Enterococcus faecium

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Enterococcus faecium

General Information

General Information Comment Organism
physiological function the enzyme is a key enzyme in the emergence of high level resistance to vancomycin in Enterococcus Enterococcus faecium