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Literature summary for 6.2.1.1 extracted from

  • Van den Berg, M.A.; de Jong-Gubbels, P.; Kortland, C.J.; van Dijken, J.P.; Pronk, J.T.; Steensma, H.Y.
    The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation (1996), J. Biol. Chem., 271, 28953-28959.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
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additional information
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Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Saccharomyces cerevisiae enzyme form Acs1p is primarily responsible for acetate activation during gluconeogenic growth. Enzyme form Acs2p is likely to be the major producer of cytosolic acetyl-CoA ?
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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2 enzyme forms Acs1p and Acs2p. Under anaerobic glucose-limited conditions only the ACS2 gene is expressed. During carbon-limited growth on glucose, ethanol, and acetate under aerobic conditions both the ACS1 gene and the ACS2 gene are expressed
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA
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Saccharomyces cerevisiae AMP + diphosphate + acetyl-CoA
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?
ATP + acetate + CoA enzyme form Acs1p is primarily responsible for acetate activation during gluconeogenic growth. Enzyme form Acs2p is likely to be the major producer of cytosolic acetyl-CoA Saccharomyces cerevisiae ?
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