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Literature summary for 6.2.1.15 extracted from

  • Wilson, D.B; Prescott, S.M.; Majerus, P.W.
    Discovery of an arachidonoyl coenzyme A synthetase in human platelets (1982), J. Biol. Chem., 257, 3510-3515.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
8,11,14-Eicosatrienoate
-
Homo sapiens
arachidonate unlabeled arachidonate inhibits arachidonate activation Homo sapiens
eicosapentaenoate slight Homo sapiens
oleate not Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
arachidonate
-
Homo sapiens
0.13
-
CoA
-
Homo sapiens
0.5
-
ATP
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ Km: 2.5 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + arachidonate + CoA Homo sapiens enzyme may control the level of free arachidonate in platelets, limiting prostaglandin synthesis by the unstimulated cell and capturing free arachidonate from extracellular sources ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 8,11,14-eicosatrienoate + CoA
-
Homo sapiens AMP + diphosphate + 8,11,14-eicosatrienoyl-CoA
-
?
ATP + arachidonate + CoA
-
Homo sapiens AMP + diphosphate + arachidonoyl-CoA
-
?
ATP + arachidonate + CoA enzyme may control the level of free arachidonate in platelets, limiting prostaglandin synthesis by the unstimulated cell and capturing free arachidonate from extracellular sources Homo sapiens ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Homo sapiens