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Literature summary for 6.2.1.16 extracted from

  • Harada, H.; Yu, F.; Okamoto, S.; Kuzuyama, T.; Utsumi, R.; Misawa, N.
    Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli (2008), Appl. Microbiol. Biotechnol., 81, 915-925.
    View publication on PubMed
Search for more literature for 6.2.1.16

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination, expression in Escherichia coli JM109, the engineered strain utilizes acetoacetate and can synthesize carotenoids, e.g. alpha-humulene, effectively, overview Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information expression of a Streptomyces mevalonate pathway gene cluster starting from HMG-CoA synthase and including isopentenyl diphosphate isomerase, idi, type 2 gene and the yeast idi type 1 and rat acetoacetate-CoA ligase genes in Escherichia coli, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetoacetate + CoA Rattus norvegicus
-
 AMP + diphosphate + acetoacetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 gene aacl
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetoacetate + CoA
-
 Rattus norvegicus AMP + diphosphate + acetoacetyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
Aacl
-
 Rattus norvegicus
Acetoacetyl-CoA ligase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus