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Literature summary for 6.2.1.16 extracted from

  • Hasegawa, S.; Noda, K.; Maeda, A.; Matsuoka, M.; Yamasaki, M.; Fukui, T.
    Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels (2012), Mol. Genet. Metab., 107, 553-560.
    View publication on PubMed
Search for more literature for 6.2.1.16

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetoacetate + CoA Mus musculus
-
 AMP + diphosphate + acetoacetyl-CoA
-
 ?
ATP + acetoacetate + CoA Mus musculus ddY
-
 AMP + diphosphate + acetoacetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus ddY
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary Mus musculus
-
liver
-
 Mus musculus
-
additional information AACS mRNA levels are dramatically increased in mice that are fed hypocholesterolemic agents Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetoacetate + CoA
-
 Mus musculus AMP + diphosphate + acetoacetyl-CoA
-
 ?
ATP + acetoacetate + CoA
-
 Mus musculus ddY AMP + diphosphate + acetoacetyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
AACS
-
 Mus musculus
Acetoacetyl-CoA synthetase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus treatment of hepatocytes with U18666A results in the upregulation of AACS gene expression up

General Information

General Information Comment Organism
metabolism AACS is involved in the pathway of ketone body metabolism, overview Mus musculus
additional information transcription mechanism of AACS, expression of AACS is regulated by cholesterol depletion, overview Mus musculus
physiological function AACS plays an important role in cholesterol homeostasis Mus musculus