Literature summary for 6.2.1.3 extracted from

Tuohetahuntila, M.; Spee, B.; Kruitwagen, H.S.; Wubbolts, R.; Brouwers, J.F.; van de Lest, C.H.; Molenaar, M.R.; Houweling, M.; Helms, J.B.; Vaandrager, A.B.
Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells (2015), Biochim. Biophys. Acta, 1851, 220-230 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
rosiglitazone	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	O35547	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatic stellate cell	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + arachidonate + CoA	-	Rattus norvegicus	AMP + diphosphate + arachidonoyl-CoA	-	?

Subunits

Subunits	Comment	Organism
?	x * 74000, SDS-PAGE	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
ACSL4	-	Rattus norvegicus
long-chain acyl-CoA synthetase 4	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	isoform ACSL4 is upregulated in activated hepatic stellate cells	up

General Information

General Information	Comment	Organism
physiological function	upregulation of isoform ACSL4 is responsible for the increase in polyunsaturated fatty acid-triacylglycerol species during activation of hepatic stellate cells, which may serve to protect cells against a shortage of polyunsaturated fatty acids required for eicosanoid secretion	Rattus norvegicus

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Release 2023.1 (January 2023)