Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | above 13.3 mM | Plasmodium knowlesi | |
diphosphate | low inhibition of oleoyl-CoA synthesis | Plasmodium knowlesi | |
oleoyl-CoA | inhibition of oleoyl-CoA synthesis | Plasmodium knowlesi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.011 | - |
palmitate | - |
Plasmodium knowlesi | |
0.028 | - |
stearate | - |
Plasmodium knowlesi | |
0.03 | - |
oleate | - |
Plasmodium knowlesi | |
0.041 | - |
linoleate | - |
Plasmodium knowlesi | |
0.048 | - |
CoA | - |
Plasmodium knowlesi | |
0.059 | - |
arachidonate | - |
Plasmodium knowlesi | |
0.73 | - |
ATP | - |
Plasmodium knowlesi |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Plasmodium knowlesi | |
Mg2+ | Km: 1.554 | Plasmodium knowlesi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium knowlesi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | of Macaca mulatta or Macaca fascicularis infected with Plasmodium knowlesi | Plasmodium knowlesi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + arachidonate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
ATP + linoleate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + linoleoyl-CoA | - |
? | |
ATP + oleate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + oleoyl-CoA | - |
? | |
ATP + palmitate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + palmitoyl-CoA | - |
? | |
ATP + stearate + CoA | - |
Plasmodium knowlesi | AMP + diphosphate + stearoyl-CoA | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
half-life of palmitoyl-CoA synthetase activity: 18 min, half-life of oleoyl-CoA synthetase activity: 4 min, half-life of arachidonyl-CoA synthetase activity: 49 min | Plasmodium knowlesi |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | - |
Plasmodium knowlesi |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.8 | 6.5: about 50% of maximal activity, 8.8: about 70% of maximal activity | Plasmodium knowlesi |