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Literature summary for 6.2.1.8 extracted from
- Oxalyl-coenzyme A synthetase from pea seed (1966), Biochim. Biophys. Acta, 118, 124-143.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hydroxylamine | inhibition of ATP-diphosphate exchange | Pisum sativum |  |
| MgCl2 | high concentrations cause a marked inhibition of ATP-diphosphate exchange | Pisum sativum | |
| NaF | slight inhibition of ATP-diphosphate exchange | Pisum sativum | |
| oxalate | high concentrations cause a slight inhibition of ATP-diphosphate exchange | Pisum sativum | |
| PCMB | inhibition of ATP-diphosphate exchange. Reversal of inhibition by GSH or cysteine | Pisum sativum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
CoA | - |
Pisum sativum | |
| 2 | - |
oxalate | - |
Pisum sativum | |
| 4 | - |
ATP | - |
Pisum sativum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Pisum sativum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lupinus sp. | - |
- |
- |
| Pisum sativum | - |
L. var. Telephone | - |
| Pumpkin | - |
- |
- |
| Triticum aestivum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Lupinus sp. | - |
| seed | - |
Triticum aestivum | - |
| seed | - |
Pisum sativum | - |
| seed | - |
Pumpkin | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + oxalate + CoA | highly specific for oxalate | Pisum sativum | AMP + diphosphate + oxalyl-CoA | - |
? | |
| CTP + oxalate + CoA | at 15% the activity relative to ATP | Pisum sativum | CMP + diphosphate + oxalyl-CoA | - |
? | |
| GTP + oxalate + CoA | at 6% of the activity relative to ATP | Pisum sativum | GMP + diphosphate + oxalyl-CoA | - |
? | |
| additional information | enzyme catalyzes oxalate-dependent and CoA-independent ATP-diphosphate exchange | Pisum sativum | ? | - |
? | |
| UTP + oxalate + CoA | at 21% the activity relative to ATP | Pisum sativum | UMP + diphosphate + oxalyl-CoA | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
ATP-diphosphate exchange | Pisum sativum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.3 | 8.6 | 6.3: about 60% of maximal activity, 8.6: about 50% of maximal activity, ATP-diphosphate exchange | Pisum sativum |
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Release 2023.1 (January 2023)
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