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Literature summary for 6.3.1.2 extracted from

  • Sonenshein, A.L.
    Control of nitrogen metabolism by Bacillus subtilis glutamine synthetase (2008), Mol. Microbiol., 68, 242-245.
No PubMed abstract available
Search for more literature for 6.3.1.2

Inhibitors

Inhibitors Comment Organism Structure
L-glutamine the enzyme is feedback inhibited Bacillus subtilis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Bacillus subtilis the enzyme is involved in the regulation of the nitrogen metabolism, overview ADP + phosphate + L-glutamine
-
 ?
additional information Bacillus subtilis feedback-inhibited glutamine synthetase acts as a molecular chaperone to stabilize the association of dimers of transcripion factor GlnR, the repressor of the glutamine synthetase operon in Bacillus subtilis, with their DNA binding sites, molecular mechanism, overview. The cell shuts off synthesis of GS, and hence of glutamine, when both the enzyme and its product are in excess. The feedback-inhibited enzyme also regulates the activity of TnrA, the global regulator of nitrogen metabolism genes, but by a very different mechanism, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
 Bacillus subtilis ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3 the enzyme is involved in the regulation of the nitrogen metabolism, overview Bacillus subtilis ADP + phosphate + L-glutamine
-
 ?
additional information feedback-inhibited glutamine synthetase acts as a molecular chaperone to stabilize the association of dimers of transcripion factor GlnR, the repressor of the glutamine synthetase operon in Bacillus subtilis, with their DNA binding sites, molecular mechanism, overview. The cell shuts off synthesis of GS, and hence of glutamine, when both the enzyme and its product are in excess. The feedback-inhibited enzyme also regulates the activity of TnrA, the global regulator of nitrogen metabolism genes, but by a very different mechanism, overview Bacillus subtilis ?
-
 ?

Synonyms

Synonyms Comment Organism
Glutamine synthetase
-
 Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bacillus subtilis