Activating Compound | Comment | Organism | Structure |
---|---|---|---|
acetylglutamate | activates | Rattus norvegicus | |
acetylglutamate | Km: 0.1 mM | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-Amino-4-oxo-5-chloropentanoic acid | - |
Rattus norvegicus | |
Mn2+ | activates | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
ATP | MgATP2- | Rattus norvegicus | |
2 | - |
NH4+ | - |
Rattus norvegicus | |
5 | - |
HCO3- | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | activates | Rattus norvegicus | |
Mg2+ | Mg2+ and Mn2+ are equally effective activators in the direction of carbamoyl phosphate synthesis, Km: 0.17 mM | Rattus norvegicus | |
Mn2+ | Mg2+ and Mn2+ are equally effective activators in the direction of carbamoyl phosphate synthesis. Excess Mn2+ inhibits | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
158000 | - |
1 * 158000, sedimentation equilibrium in 6 M guanidine hydrochloride containing DTT, predominantly exists in the monomeric form | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + NH4+ + HCO3- | - |
Rattus norvegicus | 2 ADP + phosphate + carbamoyl phosphate | - |
? | |
2 ATP + NH4+ + HCO3- | ATP in form of MnATP2- | Rattus norvegicus | 2 ADP + phosphate + carbamoyl phosphate | - |
? | |
ATP + NH4+ + CO2 + H2O | no activity with Gln | Rattus norvegicus | ADP + phosphate + carbamoylphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 158000, sedimentation equilibrium in 6 M guanidine hydrochloride containing DTT, predominantly exists in the monomeric form | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | 7.6 | - |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.3 | 8 | 50% of maximal activity at pH 6.3 and 8.0 | Rattus norvegicus |