Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[tRNAIle2]-cytidine34 + L-lysine + ATP | Escherichia coli | enzyme catalyzes the lysylation of C34 (wobble position) in the precursor tRNAIle(CAU), thereby leading to the formation of tRNAIle(lysidineAU). The formation of lysidine by this essential enzyme allows recognition of tRNAIle(lysidineCAU) by Ile-tRNA synthetase and switches the base pairing of the tRNA from AUG (Met) to AUA (Ile) | [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[tRNAIle2]-cytidine34 + L-lysine + ATP | - |
Escherichia coli | [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate | - |
? | |
[tRNAIle2]-cytidine34 + L-lysine + ATP | enzyme catalyzes the lysylation of C34 (wobble position) in the precursor tRNAIle(CAU), thereby leading to the formation of tRNAIle(lysidineAU). The formation of lysidine by this essential enzyme allows recognition of tRNAIle(lysidineCAU) by Ile-tRNA synthetase and switches the base pairing of the tRNA from AUG (Met) to AUA (Ile) | Escherichia coli | [tRNAIle2]-2-L-lysylcytidine34 + AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mesJ | - |
Escherichia coli |
TilS | - |
Escherichia coli |
TilS | tilS gene found only in bacterial genomes | Escherichia coli |
tRNAIle-lysidine synthetase | - |
Escherichia coli |
yacA | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme catalyzes the lysylation of C34 in the precursor tRNAIle(CAU), thereby leading to the formation of tRNAIle(lysidineAU). The formation of lysidine by this essential enzyme allows recognition of tRNAIle(lysidineCAU) by Ile-tRNA synthetase and switches the base pairing of the tRNA from AUG (Met) to AUA (Ile). TilS is essential and plays a crucial role in accurate decoding and hence viability of cells | Escherichia coli |