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Literature summary for 6.3.4.2 extracted from

  • van Kuilenburg, A.B.P.; Meinsma, R.; Vreken, P.; Waterham, H.R.; van Gennip, A.H.
    Isoforms of human CTP synthetase (2000), Adv. Exp. Med. Biol., 486, 257-261.
    View publication on PubMed
Search for more literature for 6.3.4.2

Cloned(Commentary)

Cloned (Comment) Organism
expression of the human type II CTP synthetase gene in the CTP synthetase-deficient mutant Escherichia coli JF618 completely abolishes the need for exogenous cytidine for their survival Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme catalyzes the rate-limiting step in synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 CTP synthetase type II
-

Source Tissue

Source Tissue Comment Organism Textmining
colonic cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UTP + NH4+
-
 Homo sapiens ADP + phosphate + CTP
-
 ?
additional information the enzyme catalyzes the rate-limiting step in synthesis of cytosine nucleotides from both de novo and uridine-salvage pathways Homo sapiens ?
-
 ?