Literature summary for 6.3.4.2 extracted from

Wylie, J.L.; Wang, L.L.; Tipples, G.; McClarty, G.
A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine (1996), J. Biol. Chem., 271, 15393-15400.

Search for more literature for 6.3.4.2

Cloned(Commentary)

Cloned (Comment)	Organism
expression of the mutant enzyme D149E in Escherichia coli	Chlamydia trachomatis

Protein Variants

Protein Variants	Comment	Organism
D149E	the single point mutation in the resistant strain L2/CPEC results in loss of CTP feedback inhibition, cells are resistant to the cytotoxic effects of cyclopentenyl cytosine	Chlamydia trachomatis

Organism

Organism	UniProt	Comment	Textmining
Chlamydia trachomatis	-	-	-
Chlamydia trachomatis L2/CPEC	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + UTP + NH4+	-	Chlamydia trachomatis	ADP + phosphate + CTP	-	?
ATP + UTP + NH4+	-	Chlamydia trachomatis L2/CPEC	ADP + phosphate + CTP	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)