Any feedback?
Literature summary for 6.3.4.3 extracted from
- The effect of nordihydroguaiaretic acid and related lignans on formyltetrahydrofolate synthetase and carboxylesterase (1984), Biochim. Biophys. Acta, 788, 167-180.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Heminordihydroguaiaretic acid | - |
Bos taurus |  |
| Heminordihydroguaiaretic acid | - |
Cavia porcellus | |
| Heminordihydroguaiaretic acid | - |
Homo sapiens | |
| Heminordihydroguaiaretic acid | - |
Mus musculus | |
| Heminordihydroguaiaretic acid | - |
Rattus norvegicus | |
| nordihydroguaiaretic acid | - |
Bos taurus | |
| nordihydroguaiaretic acid | - |
Cavia porcellus | |
| nordihydroguaiaretic acid | - |
Homo sapiens | |
| nordihydroguaiaretic acid | - |
Mus musculus | |
| nordihydroguaiaretic acid | - |
Rattus norvegicus | |
| Norisoguaiacin | - |
Bos taurus | |
| Norisoguaiacin | - |
Cavia porcellus | |
| Norisoguaiacin | - |
Homo sapiens | |
| Norisoguaiacin | - |
Mus musculus | |
| Norisoguaiacin | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
trifunctional enzyme with 10-formyltetrahydrofolate synthetase, EC 6.3.4.3, 5,10-methenyltetrahydrofolate cyclohydrolase, EC 3.5.4.9, and 5,10-methylenetetrahydrofolate dehydrogenase activity, EC 1.5.1.5 | - |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| CCRF S-180 II cell | - |
Mus musculus | - |
| HeLa cell | - |
Homo sapiens | - |
| kidney | - |
Cavia porcellus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Bos taurus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + formate + tetrahydrofolate | - |
Cavia porcellus | ADP + phosphate + 10-formyltetrahydrofolate | - |
? | |
| ATP + formate + tetrahydrofolate | - |
Mus musculus | ADP + phosphate + 10-formyltetrahydrofolate | - |
? | |
| ATP + formate + tetrahydrofolate | - |
Homo sapiens | ADP + phosphate + 10-formyltetrahydrofolate | - |
? | |
| ATP + formate + tetrahydrofolate | - |
Rattus norvegicus | ADP + phosphate + 10-formyltetrahydrofolate | - |
? | |
| ATP + formate + tetrahydrofolate | - |
Bos taurus | ADP + phosphate + 10-formyltetrahydrofolate | - |
? | |
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