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Literature summary for 6.3.4.4 extracted from
- Purification, crystallization, and properties of adenylosuccinate synthetase from rat skeletal muscle (1977), J. Biochem., 81, 859-869.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenylosuccinate | - |
Rattus norvegicus |  |
| argininosuccinate | - |
Rattus norvegicus | |
| Carbamoylphosphate | - |
Rattus norvegicus | |
| PCMB | - |
Rattus norvegicus | |
| phosphate | - |
Rattus norvegicus | |
| SO42- | - |
Rattus norvegicus | |
| succinate | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.25 | - |
Asp | L-Asp | Rattus norvegicus | |
| 0.38 | - |
Asp | GTP | Rattus norvegicus | |
| 0.7 | - |
IMP | skeletal muscle | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | 16.2% of the activation relative to Mg2+ | Rattus norvegicus | |
| Co2+ | 21.3% of the activation relative to Mg2+ | Rattus norvegicus | |
| Mg2+ | - |
Rattus norvegicus | |
| Mn2+ | 43.2% of the activation relative to Mg2+ | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
2 * 52000, SDS-PAGE | Rattus norvegicus |
| 104000 | - |
sedimentation equilibrium analysis | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + IMP + L-Asp | - |
Rattus norvegicus | GDP + phosphate + adenylosuccinate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 52000, SDS-PAGE | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 8.5 | 50% of maximal activity at pH 5.5 and 8.5 | Rattus norvegicus |
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