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Literature summary for 6.3.4.4 extracted from

  • Nomura, Y.; Nozawa, A.; Tozawa, Y.
    Biochemical analyses of ppGpp effect on adenylosuccinate synthetases, key enzymes in purine biosynthesis in rice (2014), Biosci. Biotechnol. Biochem., 78, 1022-1025 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
GDP
-
Bacillus subtilis
GDP
-
Escherichia coli
GDP
-
Oryza sativa
ppGpp
-
Bacillus subtilis
ppGpp
-
Escherichia coli
ppGpp
-
Oryza sativa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0044
-
GTP pH 7.7, 30°C Bacillus subtilis
0.0091
-
GTP isoform AdSS1, pH 7.7, 30°C Oryza sativa
0.01
-
GTP isoform AdSS2, pH 7.7, 30°C Oryza sativa
0.03
-
GTP pH 7.7, 30°C Escherichia coli

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bacillus subtilis 168
-
-
-
Escherichia coli
-
-
-
Oryza sativa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + IMP + L-aspartate
-
Bacillus subtilis GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
?
GTP + IMP + L-aspartate
-
Escherichia coli GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
?
GTP + IMP + L-aspartate
-
Oryza sativa GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
?
GTP + IMP + L-aspartate
-
Bacillus subtilis 168 GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
-
?

Synonyms

Synonyms Comment Organism
AdSS
-
Bacillus subtilis
AdSS
-
Escherichia coli
AdSS
-
Oryza sativa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.47
-
GTP pH 7.7, 30°C Bacillus subtilis
0.6
-
GTP isoform AdSS2, pH 7.7, 30°C Oryza sativa
0.64
-
GTP pH 7.7, 30°C Escherichia coli
0.98
-
GTP isoform AdSS1, pH 7.7, 30°C Oryza sativa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.005
-
GDP isoform AdSS1, pH 7.7, 30°C Oryza sativa
0.0061
-
ppGpp isoform AdSS2, pH 7.7, 30°C Oryza sativa
0.0062
-
GDP pH 7.7, 30°C Bacillus subtilis
0.0067
-
GDP isoform AdSS2, pH 7.7, 30°C Oryza sativa
0.007
-
ppGpp pH 7.7, 30°C Bacillus subtilis
0.011
-
ppGpp isoform AdSS1, pH 7.7, 30°C Oryza sativa
0.012
-
GDP pH 7.7, 30°C Escherichia coli
0.05
-
ppGpp pH 7.7, 30°C Escherichia coli

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
21
-
GTP pH 7.7, 30°C Escherichia coli
60
-
GTP isoform AdSS2, pH 7.7, 30°C Oryza sativa
107
-
GTP pH 7.7, 30°C Bacillus subtilis
108
-
GTP isoform AdSS1, pH 7.7, 30°C Oryza sativa