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Literature summary for 6.3.5.4 extracted from
- Asparagine synthesis (1974), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 10, 561-580.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aminomalonic acid | competitive versus L-Asp | Mus musculus |  |
| AMP | - |
Mus musculus | |
| AMP | - |
Rattus norvegicus | |
| Asn | - |
Mus musculus | |
| Asn | - |
Rattus norvegicus | |
| diphosphate | - |
Mus musculus | |
| diphosphate | - |
Rattus norvegicus | |
| L-2-Amino-4-oxo-5-chloropentanoic acid | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.2 | - |
ATP | - |
Mus musculus | |
| 0.58 | - |
L-Asp | - |
Rattus norvegicus | |
| 0.9 | - |
L-Asp | - |
Mus musculus | |
| 1 | - |
L-Gln | - |
Mus musculus | |
| 1.1 | - |
L-Gln | - |
Rattus norvegicus | |
| 9 | - |
NH4+ | - |
Mus musculus | |
| 120 | - |
NH4+ | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | divalent metal ion required, Mg2+ more effective than Mn2+ | Rattus norvegicus | |
| Mg2+ | Km: 23.7 | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 105000 | - |
gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukemia cell line | - |
Mus musculus | - |
| leukemia cell line | - |
Rattus norvegicus | - |
| Novikoff hepatoma cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-Asp + L-Gln | - |
Mammalia | AMP + diphosphate + Asn + Glu | - |
? | |
| ATP + L-Asp + L-Gln | - |
Mus musculus | AMP + diphosphate + Asn + Glu | - |
? | |
| ATP + L-Asp + L-Gln | - |
Rattus norvegicus | AMP + diphosphate + Asn + Glu | - |
? | |
| ATP + L-Asp + NH2OH | - |
Mus musculus | AMP + diphosphate + beta-aspartylhydroxamate | - |
? | |
| ATP + L-Asp + NH2OH | - |
Rattus norvegicus | AMP + diphosphate + beta-aspartylhydroxamate | - |
? | |
| ATP + L-Asp + NH3 | - |
Mus musculus | AMP + diphosphate + Asn | - |
? | |
| ATP + L-Asp + NH3 | - |
Rattus norvegicus | AMP + diphosphate + Asn | - |
? | |
| ATP + L-Asp + NH3 | NH4+ | Mammalia | AMP + diphosphate + Asn | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | 8 | - |
Rattus norvegicus |
| 7.6 | 8.2 | - |
Mus musculus |
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