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Literature summary for 6.4.1.1 extracted from
- Rat liver pyruvate carboxylase. Purification, detection and quantification of apo and holo forms by immuno-blotting and by an enzyme-linked immunosorbent assay (1986), Biochem. J., 236, 527-533.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate + HCO3- | Mammalia | the enzyme occupies a strategic position in the intermediary metabolism of numerous tissues. In the gluconeogenic tissues, e.g. liver, kidney, it catalyzes the first step in the synthesis of glucose from pyruvate. During lipogenesis in liver, adipose tissue and mammary gland it participates in the synthesis of acetyl groups and reducing groups for transport from the mitochondria to the cytosol. In yet other tissues it fulfills an anaplerotic function | ? | - |
? |  |
| ATP + pyruvate + HCO3- | Homo sapiens | pyruvate carboxylase deficiency in humans causes severe acidosis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mammalia | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 34 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + pyruvate + HCO3- | - |
Mammalia | ADP + phosphate + oxaloacetate | - |
? | |
| ATP + pyruvate + HCO3- | - |
Homo sapiens | ADP + phosphate + oxaloacetate | - |
? | |
| ATP + pyruvate + HCO3- | - |
Rattus norvegicus | ADP + phosphate + oxaloacetate | - |
? | |
| ATP + pyruvate + HCO3- | the enzyme occupies a strategic position in the intermediary metabolism of numerous tissues. In the gluconeogenic tissues, e.g. liver, kidney, it catalyzes the first step in the synthesis of glucose from pyruvate. During lipogenesis in liver, adipose tissue and mammary gland it participates in the synthesis of acetyl groups and reducing groups for transport from the mitochondria to the cytosol. In yet other tissues it fulfills an anaplerotic function | Mammalia | ? | - |
? | |
| ATP + pyruvate + HCO3- | pyruvate carboxylase deficiency in humans causes severe acidosis | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Homo sapiens |
| ? | x * 125000-130000, SDS-PAGE with dithiothreitol | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| biotin | enzyme contains biotin | Homo sapiens | |
| biotin | enzyme contains biotin | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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