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Literature summary for 6.4.1.1 extracted from

  • Osmani, S.A.; Marston, F.A.O.; Selmes, I.P.; Chapman, A.G.; Srutton, M.C.
    Pyruvate carboxylase from Aspergillus nidulans. Regulatory properties (1981), Eur. J. Biochem., 118, 271-278.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetyl-CoA activates in presence of either L-Asp or 2-oxoglutarate but does not activate in absence of these dicarboxylic acids. Trinitrobenzenesulfonate causes selective loss of the capacity for activation by acetyl-CoA Aspergillus nidulans

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate competitive with respect to pyruvate and at lower concentrations uncompetitive with respect to HCO3- Aspergillus nidulans
L-Asp competitive with respect to HCO3-, non-competitive with respect to pyruvate and MgATP2- Aspergillus nidulans

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Aspergillus nidulans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate + HCO3-
-
Aspergillus nidulans ADP + phosphate + oxaloacetate
-
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