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Literature summary for 6.4.1.2 extracted from

  • Price, L.J.; Herbert, D.; Moss, S.R.; Cole, D.J.; Harwood, J.L.
    Graminicide insensitivity correlates with herbicide-binding co-operativity on acetyl-CoA carboxylase isoforms (2003), Biochem. J., 375, 415-423.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.4.1.2

Inhibitors

Inhibitors Comment Organism Structure
Fluazifop
-
 Alopecurus myosuroides
Fluazifop
-
 Festuca rubra
Fluazifop
-
 Zea mays
Quizalofop
-
 Alopecurus myosuroides
Quizalofop
-
 Festuca rubra
Quizalofop
-
 Zea mays

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 acetyl-CoA cytosolic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides
0.08
-
 ATP cytosolic enzyme, pH 8.0, 30°C Zea mays
0.08
-
 ATP plastidic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides
0.08
-
 ATP plastidic enzyme, pH 8.0, 30°C Zea mays
0.11
-
 acetyl-CoA cytosolic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
0.11
-
 acetyl-CoA cytosolic enzyme, pH 8.0, 30°C Zea mays
0.11
-
 acetyl-CoA cytosolic enzyme, pH 8.0, 30°C Festuca rubra
0.12
-
 ATP cytosolic enzyme, pH 8.0, 30°C Festuca rubra
0.12
-
 acetyl-CoA plastidic enzyme, pH 8.0, 30°C Zea mays
0.14
-
 acetyl-CoA plastidic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides
0.15
-
 ATP plastidic enzyme, pH 8.0, 30°C Festuca rubra
0.16
-
 acetyl-CoA plastidic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
0.18
-
 ATP cytosolic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides
0.2
-
 acetyl-CoA plastidic enzyme, pH 8.0, 30°C Festuca rubra
0.39
-
 HCO3- cytosolic enzyme, pH 8.0, 30°C Zea mays
0.47
-
 ATP plastidic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
0.5
-
 ATP cytosolic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
1.09
-
 HCO3- plastidic enzyme, pH 8.0, 30°C Zea mays
1.15
-
 HCO3- plastidic enzyme, pH 8.0, 30°C Festuca rubra
1.25
-
 HCO3- cytosolic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
1.38
-
 HCO3- cytosolic enzyme, pH 8.0, 30°C Festuca rubra
1.38
-
 HCO3- plastidic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides
1.64
-
 HCO3- plastidic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
1.75
-
 HCO3- cytosolic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast major isoform Zea mays 9507
-
chloroplast major isoform Alopecurus myosuroides 9507
-
chloroplast major isoform Festuca rubra 9507
-
cytoplasm minor isoform Zea mays 5737
-
cytoplasm minor isoform Alopecurus myosuroides 5737
-
cytoplasm minor isoform Festuca rubra 5737
-
plastid
-
 Zea mays 9536
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
219000
-
 SDS-PAGE, cytosolic isoform Zea mays
227000
-
 SDS-PAGE, plastidic isoform Zea mays
240000
-
 SDS-PAGE, both isoforms Festuca rubra

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Zea mays key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Alopecurus myosuroides key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- Festuca rubra key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Alopecurus myosuroides
-
 'Notts-A1'-resistant biotype and strain Rothamsted
-
Festuca rubra
-
-
-
Zea mays
-
-
-

Purification (Commentary)

Purification (Comment) Organism
separation of two isoforms Zea mays
separation of two isoforms Alopecurus myosuroides
separation of two isoforms Festuca rubra

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5
-
 purified cytosolic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
24.9
-
 purified cytosolic enzyme, pH 8.0, 30°C Festuca rubra
34.9
-
 purified cytosolic enzyme, pH 8.0, 30°C Zea mays
41.3
-
 purified cytosolic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides
52.4
-
 purified plastidic enzyme from strain Notts A1, pH 8.0, 30°C Alopecurus myosuroides
154.9
-
 purified plastidic enzyme from strain Rothamsted, pH 8.0, 30°C Alopecurus myosuroides
184.2
-
 purified plastidic enzyme, pH 8.0, 30°C Festuca rubra
217
-
 purified plastidic enzyme, pH 8.0, 30°C Zea mays

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Zea mays ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Alopecurus myosuroides ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3-
-
 Festuca rubra ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Zea mays ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Alopecurus myosuroides ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Festuca rubra ADP + phosphate + malonyl-CoA
-
 ?

Cofactor

Cofactor Comment Organism Structure
biotin enzyme-bound Zea mays
biotin enzyme-bound Alopecurus myosuroides
biotin enzyme-bound Festuca rubra