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Literature summary for 6.4.1.2 extracted from

  • Thampy, G.K.; Haas, M.J.; Mooradian, A.D.
    Troglitazone stimulates acetyl-CoA carboxylase activity through a post-translational mechanism (2000), Life Sci., 68, 699-708.
    View publication on PubMed
Search for more literature for 6.4.1.2

Activating Compound

Activating Compound Comment Organism Structure
citrate
-
 Rattus norvegicus
additional information more than 200% increase in activity when rats were treated with troglitazone for 18 days Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
262000
-
 SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetyl-CoA + HCO3- Rattus norvegicus key enzyme of fatty acid biosynthesis ADP + phosphate + malonyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male Fischer rats
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0015
-
 control rats, pH 7.5, 37°C Rattus norvegicus
0.0025
-
 troglitazone treated rats, pH 7.5, 37°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetyl-CoA + HCO3-
-
 Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?
ATP + acetyl-CoA + HCO3- key enzyme of fatty acid biosynthesis Rattus norvegicus ADP + phosphate + malonyl-CoA
-
 ?

Cofactor

Cofactor Comment Organism Structure
biotin enzyme-bound Rattus norvegicus