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Literature summary for 6.4.1.2 extracted from
- Copper deficiency results in AMP-activated protein kinase activation and acetyl-CoA carboxylase phosphorylation in rat cerebellum (2008), Brain Res., 1204, 69-76.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | activated AMP-activated protein kinase, AMPK, phosphorylates and inhibits acetyl-CoA carboxylase. ACC is inhibited in Cu-deficient cerebella | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | Rattus norvegicus | first enzyme in fatty acid biosynthesis, regulated by AMP-activated protein kinase, overview | ADP + phosphate + malonyl-CoA | - |
? | |
| additional information | Rattus norvegicus | perinatal copper deficiency in rat pups inhibits the enzyme, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | activated AMP-activated protein kinase, AMPK, phosphorylates and inhibits acetyl-CoA carboxylase, AMPK is itself regulated by reversible phosphorylation | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| cerebellum | ACC is inhibited in Cu-deficient cerebella | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
| ATP + acetyl-CoA + HCO3- | first enzyme in fatty acid biosynthesis, regulated by AMP-activated protein kinase, overview | Rattus norvegicus | ADP + phosphate + malonyl-CoA | - |
? | |
| additional information | perinatal copper deficiency in rat pups inhibits the enzyme, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACC | - |
Rattus norvegicus |
| acetylCoA carboxylase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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