Application | Comment | Organism |
---|---|---|
drug development | inhibition of ACC demonstrates promising therapeutic potential for treating obesity and type 2 diabetes mellitus in transgenic mice and preclinical animal models | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone | - |
Homo sapiens | |
(2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone | - |
Homo sapiens | |
(2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone | - |
Homo sapiens | |
(2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
(2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
(2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | - |
Homo sapiens | |
1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | - |
Homo sapiens | |
1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | - |
Homo sapiens | |
1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | - |
Homo sapiens | |
1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | - |
Homo sapiens | |
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone | - |
Homo sapiens | |
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone | - |
Homo sapiens | |
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone | - |
Homo sapiens | |
1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one | - |
Homo sapiens | |
1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone | - |
Homo sapiens | |
3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide | - |
Homo sapiens | |
4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide | - |
Homo sapiens | |
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide | - |
Homo sapiens | |
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide | - |
Homo sapiens | |
4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide | - |
Homo sapiens | |
anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone | - |
Homo sapiens | |
anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | - |
Homo sapiens | |
anthracen-9-yl[(3R)-3-(morpholin-4-ylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone | i.e. CP-640186 | Homo sapiens | |
anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone | - |
Homo sapiens | |
cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone | - |
Homo sapiens | |
methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate | - |
Homo sapiens | |
additional information | disubstituted (4-piperidinyl)-piperazine derivatives act as ACC1/2 non-selective inhibitors | Homo sapiens | |
propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate | - |
Homo sapiens | |
[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | Homo sapiens | - |
ADP + phosphate + malonyl-CoA | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + acetyl-CoA + HCO3- | - |
Homo sapiens | ADP + phosphate + malonyl-CoA | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
ACC1 | - |
Homo sapiens |
ACC2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000032 | - |
ACC1/2 | Homo sapiens | 1-[4-((4-[4-((2,6-bis[4-(hydroxymethyl)phenyl]pyridin-4-yl)carbonyl)piperazin-1-yl]piperidin-1-yl)carbonyl)piperidin-1-yl]ethanone | |
0.000052 | - |
ACC1/2 | Homo sapiens | 1-(4-([4-(4-([2,6-bis(4-hydroxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | |
0.00006 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl(4-(1-[(2,5-dimethylfuran-3-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone | |
0.000066 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone | |
0.000067 | - |
ACC1/2 | Homo sapiens | 4,4'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide | |
0.000068 | - |
ACC1/2 | Homo sapiens | 1-(4-([4-(4-([2,6-bis(4-methoxyphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | |
0.000073 | - |
ACC1/2 | Homo sapiens | 3,3'-(4-[(4-(1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl)piperazin-1-yl)carbonyl]pyridine-2,6-diyl)dibenzamide | |
0.000076 | - |
ACC1/2 | Homo sapiens | 1-(4-([4-(4-([2,6-bis(4-methylphenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | |
0.000091 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl(4-[1-(cyclohexylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.000095 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl(4-[1-(cyclopentylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.000095 | - |
ACC1/2 | Homo sapiens | 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N-methylpiperidine-1-carboxamide | |
0.000102 | - |
ACC1/2 | Homo sapiens | 1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-hydroxyethanone | |
0.000102 | - |
ACC1/2 | Homo sapiens | methyl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate | |
0.000115 | - |
ACC1/2 | Homo sapiens | 1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)propan-1-one | |
0.000121 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.000126 | - |
ACC1/2 | Homo sapiens | 1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)ethanone | |
0.000131 | - |
ACC1/2 | Homo sapiens | 1-(4-([4-(4-([2,6-bis(3-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | |
0.000151 | - |
ACC1/2 | Homo sapiens | 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxamide | |
0.000155 | - |
ACC1/2 | Homo sapiens | (2,6-diphenylpyridin-4-yl)(4-(1-[(4-methoxycyclohexyl)carbonyl]piperidin-4-yl)piperazin-1-yl)methanone | |
0.000157 | - |
ACC1/2 | Homo sapiens | (2,5-dimethylfuran-3-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone | |
0.000161 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl(4-[1-(furan-2-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.000169 | - |
ACC1/2 | Homo sapiens | 1-(4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidin-1-yl)-2-methoxyethanone | |
0.000169 | - |
ACC1/2 | Homo sapiens | 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]-N,N-dimethylpiperidine-1-carboxamide | |
0.000184 | - |
ACC1/2 | Homo sapiens | 1-(4-([4-(4-([2,6-bis(4-fluorophenyl)pyridin-4-yl]carbonyl)piperazin-1-yl)piperidin-1-yl]carbonyl)piperidin-1-yl)ethanone | |
0.000239 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.000244 | - |
ACC1/2 | Homo sapiens | cyclohexyl(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone | |
0.000248 | - |
ACC1/2 | Homo sapiens | (2,6-diphenylpyridin-4-yl)(4-[1-((1-[(methylsulfonyl)carbonyl]piperidin-4-yl)carbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.00029 | - |
ACC1/2 | Homo sapiens | (1-benzoylpiperidin-4-yl)(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)methanone | |
0.000411 | - |
ACC1/2 | Homo sapiens | propan-2-yl 4-[(4-(4-[(2,6-diphenylpyridin-4-yl)carbonyl]piperazin-1-yl)piperidin-1-yl)carbonyl]piperidine-1-carboxylate | |
0.000434 | - |
ACC1/2 | Homo sapiens | (2,6-diphenylpyridin-4-yl)(4-[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.000693 | - |
ACC1/2 | Homo sapiens | [4-(1-benzoylpiperidin-4-yl)piperazin-1-yl](2,6-diphenylpyridin-4-yl)methanone | |
0.000869 | - |
ACC1/2 | Homo sapiens | (2,6-diphenylpyridin-4-yl)(4-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]piperazin-1-yl)methanone | |
0.002112 | - |
ACC1/2 | Homo sapiens | anthracen-9-yl[4-(1-benzoylpiperidin-4-yl)piperazin-1-yl]methanone |
General Information | Comment | Organism |
---|---|---|
metabolism | acetyl-CoA carboxylase is the rate limiting enzyme in de novo lipid synthesis | Homo sapiens |
physiological function | acetyl-CoA carboxylase plays important roles in modulating energy metabolism | Homo sapiens |