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Literature summary for 6.4.1.2 extracted from
- Soraphen, an inhibitor of the acetyl-CoA carboxylase system, improves peripheral insulin sensitivity in mice fed a high-fat diet (2009), Diabetes Obes. Metab., 11, 987-991.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | pharmacological inhibition of the ACC system is of potential use for treatment of key components of the metabolic syndrome, plasma and hepatic metabolic parameters after fasting and after the hyperinsulinaemic euglycaemic clamp, overview | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| ACC1 and ACC2 expression analysis | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| soraphen A | - |
Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
male C57Bl6/J mice, isozymes ACC1 and ACC2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetyl-CoA + HCO3- | - |
Mus musculus | ADP + phosphate + malonyl-CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACC1 | - |
Mus musculus |
| ACC2 | - |
Mus musculus |
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Release 2023.1 (January 2023)
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