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Literature summary for 6.4.1.2 extracted from

  • Kamata, M.; Yamashita, T.; Kina, A.; Tawada, M.; Endo, S.; Mizukami, A.; Sasaki, M.; Tani, A.; Nakano, Y.; Watanabe, Y.; Furuyama, N.; Funami, M.; Amano, N.; Fukatsu, K.
    Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors (2012), Bioorg. Med. Chem. Lett., 22, 4769-4772.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
-
Homo sapiens
1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
-
Homo sapiens
1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
-
Homo sapiens
1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00763
-
-
Homo sapiens Q13085
-
-

Synonyms

Synonyms Comment Organism
ACC1
-
Homo sapiens
ACC2
-
Homo sapiens
acetyl-CoA carboxylase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000049
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
0.0000059
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
0.0000061
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
0.0000081
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.00002
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000021
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-ethylurea
0.000022
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000022
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)urea
0.000025
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-7-methoxy-1-benzothiophen-2-yl)-3-methylurea
0.000041
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2,3-diethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.000043
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000048
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.000051
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxohexahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazocin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000075
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.000087
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a][1,2]diazepin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.00012
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(2,3-dimethyl-1,4-dioxo-2,3,7-triazaspiro[4.5]dec-7-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.00013
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.00017
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.0002
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea
0.00023
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.00033
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxodihydro-1H,5'H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyrazol]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-ethylurea
0.00036
-
pH and temperature not specified in the publication Homo sapiens 1-(3-[[4-(1',3'-dioxotetrahydro-1H-spiro[piperidine-3,2'-pyrazolo[1,2-a]pyridazin]-1-yl)piperidin-1-yl]carbonyl]-1-benzothiophen-2-yl)-3-methylurea