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Literature summary for 6.5.1.1 extracted from

  • Ramos, W.; Liu, G.; Giroux, C.N.; Tomkinson, A.E.
    Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOR005c, a homolog of mammalian DNA ligase IV (1998), Nucleic Acids Res., 26, 5676-5683.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
in vitro transcription and translation Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
90000
-
x * 90000, SDS-PAGE Saccharomyces cerevisiae
104000
-
x * 104000, deduced from nucleotide sequence Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Saccharomyces cerevisiae probably involved in non-homologous end joining repair mechanism AMP + diphosphate + (deoxyribonucleotide)m+n
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q08387 inactivation of DNL4 gene causes temperature-sensitive growth
-

Purification (Commentary)

Purification (Comment) Organism
hydroxyapatite column, partially purified Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Saccharomyces cerevisiae AMP + diphosphate + (deoxyribonucleotide)m+n
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m probably involved in non-homologous end joining repair mechanism Saccharomyces cerevisiae AMP + diphosphate + (deoxyribonucleotide)m+n
-
?

Subunits

Subunits Comment Organism
? x * 90000, SDS-PAGE Saccharomyces cerevisiae
? x * 104000, deduced from nucleotide sequence Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Dnl4
-
Saccharomyces cerevisiae