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Literature summary for 6.5.1.1 extracted from

  • Waterworth, W.M.; Kozak, J.; Provost, C.M.; Bray, C.M.; Angelis, K.J.; West, C.E.
    DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks (2009), BMC Plant Biol., 9, 79.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Arabidopsis thaliana
-
AMP + diphosphate + (deoxyribonucleotide)n+m
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Arabidopsis thaliana AMP + diphosphate + (deoxyribonucleotide)n+m
-
?

Synonyms

Synonyms Comment Organism
DNA ligase I
-
Arabidopsis thaliana
LigI
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
ATP
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction knockout mutants of lig1 are lethal. lig1-RNAi lines with reduced levels of LIG1 display slower repair of single strand breaks and also double strand breaks Arabidopsis thaliana
physiological function LIG1 is involved in repair of of single strand breaks and double strand breaks Arabidopsis thaliana