Cloned (Comment) | Organism |
---|---|
dI and dIII domains separately expressed in Escherichia coli | Rhodospirillum rubrum |
dIII domain expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Rhodospirillum rubrum |
dI2dIII complex with bound NAD+ and NADP+, NADH and NADPH, and ADP-ribose and NADPH | Rhodospirillum rubrum |
dIII domain in the presence of NADPH | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rhodospirillum rubrum | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + NADP+ | Rhodospirillum rubrum | links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction | NAD+ + NADPH | - |
r | |
NADH + NADP+ | Homo sapiens | links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction | NAD+ + NADPH | - |
r | |
NADPH + NAD+ + H+[side 1] | Rhodospirillum rubrum | - |
NADP+ + NADH + H+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13423 | - |
- |
Rhodospirillum rubrum | - |
- |
- |
Rhodospirillum rubrum | Q2RSB2 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Rhodospirillum rubrum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + NADP+ | - |
Rhodospirillum rubrum | NAD+ + NADPH | - |
r | |
NADH + NADP+ | - |
Homo sapiens | NAD+ + NADPH | - |
r | |
NADH + NADP+ | links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction | Rhodospirillum rubrum | NAD+ + NADPH | - |
r | |
NADH + NADP+ | links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, provides NADPH for biosynthesis and glutathione reduction | Homo sapiens | NAD+ + NADPH | - |
r | |
NADPH + NAD+ + H+[side 1] | - |
Rhodospirillum rubrum | NADP+ + NADH + H+[side 2] | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | monomer composed of three domains dI, dII, and dIII | Rhodospirillum rubrum |
dimer | monomer composed of three domains dI, dII, and dIII | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
proton-translocating transhydrogenase | - |
Rhodospirillum rubrum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD(P)+ | - |
Rhodospirillum rubrum | |
NAD(P)+ | - |
Homo sapiens | |
NAD(P)H | - |
Rhodospirillum rubrum | |
NAD(P)H | - |
Homo sapiens |