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Literature summary for 7.1.1.1 extracted from

  • Sauer, U.; Canonaco, F.; Heri, S.; Perrenoud, A.; Fischer, E.
    The soluble and membrane-bound transhydrogenases UdhA and PntAB have divergent functions in NADPH metabolism of Escherichia coli (2004), J. Biol. Chem., 279, 6613-6619.
    View publication on PubMed
Search for more literature for 7.1.1.1

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + NADP+ Escherichia coli links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, major source of NADPH NAD+ + NADPH
-
 r
NADPH + NAD+ + H+[side 1] Escherichia coli
-
 NADP+ + NADH + H+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli
-
 strain MG1655, wild type strain and enzyme deficient mutant, mutant strain displays very poor growth rates
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+
-
 Escherichia coli NAD+ + NADPH
-
 r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, major source of NADPH Escherichia coli NAD+ + NADPH
-
 r
NADPH + NAD+ + H+[side 1]
-
 Escherichia coli NADP+ + NADH + H+[side 2]
-
 ?
NADPH + oxidized acetyl pyridine adenine dinucleotide + H+[side 1]
-
 Escherichia coli NADP+ + reduced acetyl pyridine adenine dinucleotide + H+[side 2]
-
 r

Synonyms

Synonyms Comment Organism
PntAB
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
 Escherichia coli
NAD(P)H
-
 Escherichia coli

General Information

General Information Comment Organism
metabolism transhydrogenase PntAB is a major source of NADPH that is required for biosynthesis in Escherichia coli Escherichia coli