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Literature summary for 7.1.1.2 extracted from
- The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria (2006), Proc. Natl. Acad. Sci. USA, 103, 7607-7612.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| capsaicin | - |
Bos taurus |  |
| Piericidin A | - |
Bos taurus | |
| rotenone | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00005 | - |
NADH | apparent value, for superoxide production, at 32°C and pH 7.5 | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial membrane | - |
Bos taurus | 31966 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 ferricytochrome c + NADH | - |
Bos taurus | 2 ferrocytochrome c + NAD+ + H+ | - |
? | |
| NADH + O2 | addition of NADH, but not decylubiquinol, leads to superoxide production | Bos taurus | NAD+ + superoxide radical | - |
? | |
| NADH + ubiquinone | - |
Bos taurus | NAD+ + ubiquinol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| complex I | - |
Bos taurus |
| NADH:ubiquinone oxidoreductase | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Bos taurus | |
| NADH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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