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Literature summary for 7.1.1.2 extracted from

  • Bao, H.G.; Zhao, C.J.; Li, J.Y.; Wu, C.h.
    Association of MT-ND5 gene variation with mitochondrial respiratory control ratio and NADH dehydrogenase activity in Tibet chicken embryos (2007), Anim. Genet., 38, 514-516.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information in m.1627C animals, the enzyme activity value under normal oxygen is significantly lower than that under simulated hypoxia Gallus gallus

Application

Application Comment Organism
additional information missense mutation in the MT-ND5 subunit of NADH dehydrogenase in Tibet chicken breed. Significant differences between animals carrying mitochondria with the EF493865.1:m.1627A versus EF493865.1:m.1627C alleles for respiratory control ratio and enzyme activity. MT-ND5 gene variation is significantly associated with brain mitochondrial respiratory function in Tibet chicken embryos under hypoxia, which identifies MT-ND5 as a candidate gene for adaptation to hypoxia (or high hatchability under hypoxia) in Tibet chickens Gallus gallus

Inhibitors

Inhibitors Comment Organism Structure
additional information in m.1627A animals, the enzyme activity value under normal oxygen is significantly higher than that under simulated hypoxia Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Gallus gallus 5739
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
Tibet chicken
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Gallus gallus
-
embryo
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone + H+
-
Gallus gallus NAD+ + ubiquinol
-
?

Synonyms

Synonyms Comment Organism
complex I
-
Gallus gallus
NADH dehydrogenase
-
Gallus gallus